1.
Indian J Physiol Pharmacol
;
1975 Jan-Mar; 19(1): 34-8
Article
in English
| IMSEAR
| ID: sea-108466
ABSTRACT
Two basic anilides EA-7 and EA-8 were investigated for their antispasmodic activity against a variety of spasmogens on different tissues from different species of animals and comparison was made with lignocaine. EA-8 was found to be the most potent in this respect, followed by EA-7 and lignocaine. The antispasmodic potency does not correspond to their local anaesthetic potency. This suggests a direct depressant effect on tissues.
Subject(s)
Acetylcholine/antagonists & inhibitors , Anesthetics, Local/pharmacology , Anilides/pharmacology , Animals , Aorta/drug effects , Barium/antagonists & inhibitors , Depression, Chemical , Epinephrine/antagonists & inhibitors , Guinea Pigs , Histamine H1 Antagonists , Ileum/drug effects , Lidocaine/pharmacology , Muscle Contraction/drug effects , Muscle, Smooth/drug effects , Norepinephrine/antagonists & inhibitors , Rabbits , Rats , Trachea/drug effects
2.
Indian J Physiol Pharmacol
;
1974 Apr-Jun; 18(2): 97-101
Article
in English
| IMSEAR
| ID: sea-108099